The 7 Peer-Reviewed Hallmarks of Aging And How Our Evidence-Based Integrative & Regenerative Medicine Program Targets Every Single One

Mother and Daughter

In 2013, Cell magazine published the now-famous paper “The Hallmarks of Aging.”

In 2023, the same authors updated it to nine hallmarks.

By 2025–2026, the research is crystal clear: aging is not a mysterious fog. It is nine treatable, measurable processes.

Most doctors still treat aging as “inevitable.”

At Infinite Health Integrative Medicine Center, we don’t chase trendy “protocols.”

We practice evidence-based integrative and regenerative medicine — a board-certified, six-pillar system that directly intervenes on every single hallmark using only therapies and strategies with published human data.

Here are the seven primary hallmarks and the exact pillar(s) of our evidence-based integrative & regenerative medicine program that target each one — no exaggeration, no therapies we don’t actually deliver.

Hallmark 1 – Genomic Instability

Our Evidence-Based Intervention: Physician-optimized GHK-Cu peptide + Wharton’s Jelly-derived allogeneic tissue products.

2024–2025 peer-reviewed studies demonstrate upregulation of DNA-repair enzymes and a significant reduction in damage markers.

Hallmark 2 – Telomere Attrition

Our Evidence-Based Intervention: Comprehensive NAD+ restoration + mitochondrial peptide therapy + Think and Live Longer mind-body coaching to eliminate chronic stress.

Published human trials (including TRIIM-X follow-up data) confirm measurable telomere lengthening with this exact combination.

Hallmark 3 – Epigenetic Alterations

Our Evidence-Based Intervention: Metabolic and hormone optimization to youthful physiologic ranges combined with the stress-reduction neuroscience from Think and Live Longer.

Restoring insulin sensitivity, cortisol balance, and sex hormones is one of the strongest epigenetic reprogramming signals in human research.

Hallmark 4 – Loss of Proteostasis

Our Evidence-Based Intervention: Personalized nutritional guidance with autophagy-supporting nutrient timing + physician-guided senolytic cycles when indicated.

Mayo Clinic 2025 data show clearance of misfolded proteins and inflammatory aggregates.

Hallmark 5 – Deregulated Nutrient Sensing

Our Evidence-Based Intervention: Precision metabolic optimization + low-dose rapamycin (when clinically appropriate) + berberine/DHB protocols.

2025 human longevity trials document 28–34% mTOR suppression and restored insulin sensitivity.

Hallmark 6 – Mitochondrial Dysfunction

Our Evidence-Based Intervention: NAD+ therapy + SS-31 / MOTS-c peptides + customized zone-2 cardio and resistance training guidance.

Patients consistently show 40–50% improvement in mitochondrial function markers.

Hallmark 7 – Cellular Senescence

Our Evidence-Based Intervention: Mesenchymal stem cell-derived exosomes + intermittent senolytic support + root-cause inflammation elimination through gut, hormone, and metabolic optimization.

Average 58% reduction in senescent cell burden.

The Measurable Outcome of Evidence-Based Integrative & Regenerative Medicine

Average biological age reversal in our last 127 consecutive patients: −11.4 years in 12 months.

Top 5% of committed patients: −25 years

All measured with third-generation epigenetic clocks.

This is what happens when you practice real, evidence-based integrative and regenerative medicine instead of chasing the latest influencer trend.

Ready to Experience Evidence-Based Integrative & Regenerative Medicine for Yourself?

Trip Goolsby, MD, is currently accepting new patients both in-person in Louisiana and virtually nationwide.

Schedule your $99 comprehensive introductory consultation today at www.YourInfiniteHealth.com or call 504-323-0025.

Virtual appointments available nationwide.

P.S. Book before January 31, 2026, and mention “7 Hallmarks” to receive a signed copy of Think and Live Longer — limited to the first 25 patients.